Publications

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Lipid Nanoparticle Characterization

The HTS platform enables systematic characterization of lipid nanoparticles to optimize cargo delivery in support of therapeutic development and translational research. By combining high-throughput RiboGreen, immunofluorescence, and luciferase assays, the platform provides integrated, multiparametric readouts of encapsulation efficiency, intracellular delivery, and functional cargo expression.

Continuous purification of mRNA by precipitation and sequential TFF

Maria del Carme Pons Royo; Tyler Arnold; Isabella Perez Rodriguez; Nicole Ostrovsky; Mushriq Al-Jazrawe; Andrew Hatas; Allan S. Myerson; Richard D. Braatz

Separation and Purification Technology • 2025

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Manufacturing mRNA-Loaded Lipid Nanoparticles with Precise Size and Morphology Control

Cedric Devos; Aniket Udepurkar; Peter Sagmeister; Ariana S. Hodlewsky; Julie Chen; Andrew Hatas; Nicole Ostrovsky; Mushriq Al-Jazrawe; Joy I. Ren; Andy Y. Liu; Allan S. Myerson; Richard D. Braatz

ACS Nano • 2025

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Purification of messenger RNA directly from crude IVT using polyethylene glycol and NaCl precipitation

Maria del Carme Pons Royo; Tyler Arnold; Isabella Perez Rodriguez; Nicole Ostrovsky; Mushriq Al-Jazrawe; Andrew Hatas; Vico Tenberg; Allan S. Myerson; Richard D. Braatz

Process Biochemistry • 2025

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