Solving complex biomedical questions takes more than just collecting more data—it requires innovative assays, novel study systems, and automated processes that produce consistent, high-quality results. Given the breadth of biomedical research, we often need custom solutions and infrastructure for unique samples, devices, and readouts. At HTS, we aim to democratize data production and analysis so we empower all researchers to extract meaningful insights.
We welcome collaborations with investigators interested in leveraging our platform. Contact us to schedule an initial consultation and develop a tailored cost estimate based on your project scope.
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We operate three integrated automation clusters that support upstream preparation, assay setup, and high-throughput readout. These systems are designed to execute multistep protocols across a wide range of experimental modalities, with minimal manual intervention and full data traceability.
High-content screening (HCS) is an image-based approach that combines automated microscopy and quantitative analysis to extract rich, multiparametric data from cells. It enables detailed measurement of features such as morphology, organelle structure, and protein localization in response to genetic or chemical perturbations. It is used in drug discovery and systems biology to profile cellular responses at scale.
At HTS, we offer high-speed, high-resolution confocal and widefield imaging using the Operetta CLS, supporting both fixed and live-cell assays. Our workflows include time-lapse imaging of 2D and 3D cellular models under full environmental control, enabling dynamic phenotypic analysis over time. For data analysis, we provide both instrument-integrated machine learning tools and support for custom ML/AI pipelines developed in-house.
Functional precision medicine (FPM) uses patient-derived samples—such as tumor resections, biopsies, ascites, or organoids—to directly measure therapeutic responses. By integrating these human-relevant experimental systems (aligned with emerging New Approach Methodologies, or NAMs), FPM generates phenotypic data that captures the complexity of cellular heterogeneity, microenvironmental influences, and adaptive resistance that shape treatment outcomes. This makes FPM a powerful complement to traditional precision medicine, especially in contexts where molecular profiles alone fail to accurately predict response.
At HTS, we receive fresh clinical specimens and rapidly process them for high-throughput functional profiling under rigorously standardized conditions. Leveraging automation, multiplexed perturbations, and single-cell analytics, our platform applies NAMs-aligned practices to produce reproducible, mechanistically informative data. By integrating functional phenotypes with molecular context, we help identify treatment strategies that may be overlooked by genomic profiling alone and generate multimodal datasets that bridge preclinical discovery with patient-specific therapy selection.
We apply our expertise in bioinformatics and machine learning to accelerate research.
We believe more, better insights will be generated when barriers to analysis are minimized.
We work with our collaborators to develop data portals that fit project needs. Powered by custom APIs built for each project.
A snapshot of key devices in our automation clusters. Contact us for full inventory, training, and scheduling. Base rates are available at the KI SBC pricing page.
Confocal imaging for phenotypic and time-lapse assays in multiwell plates (up to 1536). Z-stacking for organoids, and environmental control for live-cell imaging. Supports Cell Painting. Built-in image analysis software for real-time data generation.
Multimode reader for fluorescence, luminescence, absorbance, AlphaLISA, and kinetic assays. Supports live-cell monitoring with environmental control, on-deck injectors, and flexible well formats (up to 1536).
High-capacity, programmable liquid handler including serial dilutions, plate reformatting, and cherry picking. Equipped with a cooling block, a 96-channel head, 8-channel independently addressable tips, and pin tool for precision transfers. Allows walk-away ELISA, immunofluorescence, and Cell Painting workflows.
All-in-one washer-dispenser that combines rapid full-plate washing with up to three reagent dispensing modules. It supports 96, 384, and 1536-well formats, and integrates syringe and peristaltic pumping.
A high-density ambient sample storage carousel that delivers labware in as little as 12 seconds. It supports plates, tip boxes, and deep-well formats, features random access retrieval, and barcode-based stacker identification.
An automated incubator capable of storing up to 240 microtiter plates (MTP) with a 23 mm pitch. Its periscope lift mechanism moves samples while the cassettes remain stationary, minimizing vibration.
A compact, robot-accessible microplate centrifuge designed for integration into automated workflows. It features low vibration and noise control, a dual-bucket rotor supporting two plates, and top speeds up to 3,000 RPM (~1,000xg) for rapid plate spin-downs.
A six-axis Stäubli robot arm with integrated barcode scanner, lid handler, and plate orienter automates identity-aware routing. Orchestrated by the Cellario scheduler software, it enables coordination of complex, multi-step workflows.
Precise, contact-free acoustic liquid transfers down to 2.5 nanoliters. It's especially valuable for building drug panels, generating dose responses, randomizing dispense locations, and assembling combinatorial mixtures in high-throughput screens.
Use-friendly multi-channel pipetting in sterile BL2 biosafety cabinet. Accessories include multi-reservoir holder, plate tilter, and cooling block.
